OPEC study: An international multicenter study of ovarian preservation in endometrial cancers
Akgor U. Ayhan A. Shushkevich A. Ozdal B. Angelou K. Akbayır O. Kaidarova D. Ulrikh E. Stepanyan A. Ortac F. Aliyev S. Ozgul N. Taranenka S. Haberal A. Salman C. Seyhan A. Selcuk I. Haidopoulos D. Akıllı H. Bolatbekova R. Alaverdyan A. Taskin S. Murshudova S. Batur M. Berlev I. Gultekin M.
November 2022John Wiley and Sons Ltd
International Journal of Gynecology and Obstetrics
2022#159Issue 2550 - 556 pp.
Objective: To evaluate the feasibility and oncological safety of ovarian preservation in early stage endometrial adenocarcinoma (EC) patients aged 40 and below. Methods: A total of 11 institutions from eight countries participated in the study. 169 of 5898 patients aged ≤40 years were eligible for the study. Patients with EC treated between March 2007 and January 2019 were retrospectively assessed. Results: The median duration of follow-up after EC diagnosis was 59 months (4–187). Among 169 participants, ovarian preservation surgery (OPS) was performed in 54 (31.9%), and BSO was performed in 115 (68.1%) patients. Although patients younger than 30 years of age were more likely to have OPS than patients aged 30 to 40 years (20.4% vs. 9.6%, P = 0.021), there was no significant difference by the mean age. There were no other relevant baseline differences between OPS and BSO groups. The Kaplan–Meier analysis revealed no difference in either the overall survival (P = 0.955) or recurrence-free survival (P = 0.068) among patients who underwent OPS, and BSO. Conclusion: OPS appears to be safe without having any adverse impact on survival in women aged ≤40 years with FIGO Stage I EC.
early-stage , endometrial cancer , ovarian preservation , young women
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Department of Gynecologic Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Baskent University, Ankara, Turkey
Department of Gynecologic Oncology, N.N. Alexandrov Cancer Center of Belarus, Minsk, Belarus
Department of Gynecologic Oncology, Ankara, Turkey
Gynecologic Oncology Unit, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, University of Athens, Athens, Greece
Department of Gynecologic Oncology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey
Oncogynecology Center, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan
North-Western State Medical University, N.N. Petrov Research Institute of Oncology, Saint-Petersburg, Russian Federation
Department of Gynecologic Oncology, NAIRI Medical Center, Yerevan, Armenia
Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, School of Medicine, Ankara University, Ankara, Turkey
National Center of Oncology, Baku, Azerbaijan
Department of Gynecologic Oncology
Division of Gynecologic Oncology
Department of Gynecologic Oncology
Department of Gynecologic Oncology
Gynecologic Oncology Unit
Department of Gynecologic Oncology
Oncogynecology Center
North-Western State Medical University
Department of Gynecologic Oncology
Division of Gynaecologic Oncology
National Center of Oncology
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