A clinical case of diagnosis of breast cancer in patients with family history of BRCA mutations 1

Aitmagambetova M. Smagulova G. Bekmukhambetov Y. Zavalyonnaya O. Tulyaeva A.
2021 Via Medica

Reports of Practical Oncology and Radiotherapy
2021 #26 Issue 3 463 - 469 pp.

Background: The incidence of breast cancer is growing rapidly worldwide (1.7 million new cases and 600,000 deaths per year). Moreover, about 10% of breast cancer cases occur in young women under the age of 45. The aim of the study was to report a rare case of BRCA 1-mutated breast cancer in a young patient with multiple affected relatives. Breast cancer is due to a genetic predisposition with BRCA1 and BRCA2 representing a significant proportion of families with a very high risk of developing the disease over a lifetime of up to 50–80%. Case presentation: In this paper we report a case of a 29-year-old woman with a confirmed diagnosis of left breast carcinoma. Conclusions: Mutations of the BRCA1 gene were revealed in the patient, in two of her sisters, brother and brother’s daughter.

BRCA mutation , breast cancer , case report , heredity

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West Kazakhstan Marat Ospanov Medical University, Kazakhstan
National Chamber of Health, Esil District, Kazakhstan

West Kazakhstan Marat Ospanov Medical University
National Chamber of Health

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026