Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation
Ainayev Y. Zhanbyrbekuly U. Gaipov A. Kissamedenov N. Zhaparov U. Suleiman M. Urazova S. Rakhmetova N. Turebayev D. Keulimzhayev N. Zhankina R. Khairli G.
July 2022Springer Science and Business Media B.V.
International Urology and Nephrology
2022#54Issue 71545 - 1550 pp.
Background: Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie’s disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment. Objectives: We aimed to evaluate the efficiency and safety of plaque incision and tunica vaginalis of testis grafting in PD. Methods: This was a prospective analysis. Erectile dysfunction was assessed via International Index of Erectile Function Questionnaire (IIEF-5). Penile Doppler ultrasound was performed to assess peak systolic velocity (PSV) and end-diastolic velocity (EDV). Postoperative follow-ups were scheduled at 3, 12, and 24 months. Results: Twenty patients (mean age 47.2 ± 10.8 years) were included. The mean preoperative penile curvature was 48 ± 6.6°. The technical success rate was 100% at 3 months and 90% at 24 months. At follow-up visits, mean erect penile length was no different from the baseline. The baseline mean IIEF-5 score was 18.4 ± 2.5. The mean IIEF-5 score was 20.6 ± 2.6 at 24-month visit (p < 0.0001). Mean PSV significantly increased, while EDV significantly reduced after surgery. There were no serious complications related to surgery. Conclusions: We conclude that surgical reconstruction of penile curvature with tunica vaginalis grafting was a safe and effective procedure in PD.
Curvature , Erectile dysfunction , Penile surgery , Peyronie’s disease , Tunica vaginalis
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Department of Urology and Andrology, Astana Medical University, Beibitshilik Street #49/a, Nur-Sultan, 010000, Kazakhstan
School of Medicine, Department of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Department for Reception and Diagnosis, JSC ‘National Center of Neurosurgery’, Nur-Sultan, Kazakhstan
Department of General Medical Practice No. 3, Astana Medical University, Nur-Sultan, Kazakhstan
Department of Microbiology and Virology Named After Sh. I. Sarbasova, Astana Medical University, Nur-Sultan, Kazakhstan
Department of Surgery with an Angiosurgery and Plastic Surgery Course, Astana Medical University, Nur-Sultan, Kazakhstan
Department of Urology and Andrology
School of Medicine
Department for Reception and Diagnosis
Department of General Medical Practice No. 3
Department of Microbiology and Virology Named After Sh. I. Sarbasova
Department of Surgery with an Angiosurgery and Plastic Surgery Course
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