Cardiac remodelling – Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Aimo A. Vergaro G. González A. Barison A. Lupón J. Delgado V. Richards A.M. de Boer R.A. Thum T. Arfsten H. Hülsmann M. Falcao-Pires I. Díez J. Foo R.S.Y. Chan M.Y.Y. Anene-Nzelu C.G. Abdelhamid M. Adamopoulos S. Anker S.D. Belenkov Y. Gal T.B. Cohen-Solal A. Böhm M. Chioncel O. Jankowska E.A. Gustafsson F. Hill L. Jaarsma T. Januzzi J.L. Jhund P. Lopatin Y. Lund L.H. Metra M. Milicic D. Moura B. Mueller C. Mullens W. Núñez J. Piepoli M.F. Rakisheva A. Ristić A.D. Rossignol P. Savarese G. Tocchetti C.G. van Linthout S. Volterrani M. Seferovic P. Rosano G. Coats A.J.S. Emdin M. Bayes-Genis A.
June 2022 John Wiley and Sons Ltd

European Journal of Heart Failure
2022 #24 Issue 6 944 - 958 pp.

In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with heart failure with reduced ejection fraction because most studies on cardiac remodelling focused on this setting.

Biomarkers , Ejection fraction , Heart failure , Imaging , Predictors , Remodelling , Therapies

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Scuola Superiore SantAnna, Pisa, Italy
Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy
CIMA Universidad de Navarra, and IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
CIBERCV, Carlos III Institute of Health, Madrid, Spain
Institut del Cor, Hospital Universitari Germans Trias i Pujol Badalona, Barcelona, Spain
University of Otago, Dunedin, New Zealand
Department of Cardiology, University Medical Centre Groningen, Groningen, Netherlands
Clinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany
Faculty of Medicine, University of Porto, Porto, Portugal
Center for Applied Medical Research, Pamplona, Spain
Department of Medicine, Yong Loo-Lin School of Medicine, National University Hospital, Singapore, Singapore
Faculty of Medicine, Cairo University, Cairo, Egypt
2nd Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Athens, Greece
Department of Cardiology (CVK), and Berlin Institute of Health Center for Regenerative Therapy (BCRT), German Center for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Berlin, Germany
Lomonosv Moscow State University, Moscow, Russian Federation
Cardiology Department, Rabin Medical Center, Beilinson, Israel
Hospital Lariboisière, Paris, France
University of the Saarland, Homburg/Saar, Germany
Emergency Institute for Cardiovascular Diseases ‘Prof. C.C. Iliescu’ Bucharest, University of Medicine Carol Davila, Bucharest, Romania
Institute of Heart Disases, Wroclaw Medical University, Wroclaw, Poland
Heart Centre, Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark
Queens University Belfast, Belfast, United Kingdom
Linkoping University, Linkoping, Sweden
Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, MA, United States
University of Glasgow, Glasgow, United Kingdom
Volgograd State Medical University, Volgograd, Russian Federation
Department of Medicine, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
Cardiology, ASST Spedali Civili; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy
University of Zagreb School of Medicine, Zagreb, Croatia
Cardiology Department, Porto Armed Forces Hospital, Porto, Portugal
Department of Cardiology, University Hospital, Basel, Switzerland
Hospital Oost-Limburg, Genk, Belgium
Hospital Clínico Universitario de Valencia, INCLIVA, Universidad de Valencia, Valencia, Spain
Cardiology Division, Castelsangiovanni Hospital, Castelsangiovanni, Italy
Scientific Research Institute of Cardiology and Internal Medicine, Almaty, Kazakhstan
Department of Cardiology, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Université de Lorraine, Centre dInvestigations Cliniques-Plurithématique 1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France
Cardio-Oncology Unit, Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy
Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany
IRCCS San Raffaele, Rome, Italy
Serbian Academy of Sciences and Arts, Belgrade, Serbia
St. Georges Hospitals, NHS Trust, University of London, London, United Kingdom
University of Warwick, Coventry, United Kingdom
Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

Scuola Superiore SantAnna
Cardiology Division
CIMA Universidad de Navarra
CIBERCV
Institut del Cor
University of Otago
Department of Cardiology
Clinical Division of Cardiology
German Centre for Cardiovascular Research (DZHK)
Faculty of Medicine
Center for Applied Medical Research
Department of Medicine
Faculty of Medicine
2nd Department of Cardiovascular Medicine
Department of Cardiology (CVK)
Lomonosv Moscow State University
Cardiology Department
Hospital Lariboisière
University of the Saarland
Emergency Institute for Cardiovascular Diseases ‘Prof. C.C. Iliescu’ Bucharest
Institute of Heart Disases
Heart Centre
Queens University Belfast
Linkoping University
Massachusetts General Hospital and Baim Institute for Clinical Research
University of Glasgow
Volgograd State Medical University
Department of Medicine
Cardiology
University of Zagreb School of Medicine
Cardiology Department
Department of Cardiology
Hospital Oost-Limburg
Hospital Clínico Universitario de Valencia
Cardiology Division
Scientific Research Institute of Cardiology and Internal Medicine
Department of Cardiology
Faculty of Medicine
Université de Lorraine
Cardio-Oncology Unit
Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin
IRCCS San Raffaele
Serbian Academy of Sciences and Arts
St. Georges Hospitals
University of Warwick
Department of Medicine

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