Vitamin D Deficiency and Maternal Diseases as Risk Factors for the Development of Macrosomia in Newborns
Ailbayeva N. Alimbayeva A. Yurkovskaya O. Faizova R. Tanatarov S. Taiorazova G. Abylgazinova A. Orekhov A. Jamedinova U. Pivina L.
October 2024Multidisciplinary Digital Publishing Institute (MDPI)
Children
2024#11Issue 10
Background: The aim is to assess the association between the level of vitamin D, maternal diseases, and macrosomia in newborns. Methods: This study included 258 full-term newborns (86 newborns with macrosomia; and 172 newborns with normal weight). Enzyme immunoassays for the determination of vitamin D were performed. Results: Newborns with macrosomia were statistically significantly more likely to have severe vitamin D deficiency compared with control (13.5 ± 6.7 ng/mL vs. 21.3 ± 12.1 ng/mL; p < 0.05). In the main group, severe deficiency was found in 40.7% of newborns, in the control group this rate was 5.8% (χ2 = 71,788, df = 3, p < 0.001). Multiple regression analysis shows that statistically significant risk factors for the development of macrosomia were vitamin D deficiency in the cord blood (OR = 2.29), maternal age over 36 years old (OR = 19.54), and hypothyroidism (OR = 9.35). Conclusion: the results of our study demonstrate relationship between macrosomia in newborns and vitamin D deficiency in the cord blood, maternal overweight and obesity, maternal age and thyroid disease.
macrosomia , maternal hypothyroidism , maternal obesity , newborns , risk factors , vitamin D
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Department of Pediatrics and Medical Rehabilitation Named after Tusupova D.M., Semey Medical University, Semey, 071400, Kazakhstan
Department of General Medical Practice, Semey Medical University, Semey, 071400, Kazakhstan
Center for Nuclear Medicine and Oncology, Semey, 071400, Kazakhstan
Department of Internal Medicine, Semey Medical University, Semey, 071400, Kazakhstan
Epidemiology and Biostatistics Department, Semey Medical University, Semey, 071400, Kazakhstan
Department of Emergency Medicine, Semey Medical University, Semey, 071400, Kazakhstan
Department of Pediatrics and Medical Rehabilitation Named after Tusupova D.M.
Department of General Medical Practice
Center for Nuclear Medicine and Oncology
Department of Internal Medicine
Epidemiology and Biostatistics Department
Department of Emergency Medicine
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