Cardiovascular Response to Intraneural Right Vagus Nerve Stimulation in Adult Minipig
Agnesi F. Zinno C. Strauss I. Dushpanova A. Casieri V. Bernini F. Terlizzi D. Gabisonia K. Paggi V. Lacour S.P. Lionetti V. Micera S.
October 2024International Neuromodulation Society
Neuromodulation
2024#27Issue 71187 - 1195 pp.
Objective: This study explored intraneural stimulation of the right thoracic vagus nerve (VN) in sexually mature male minipigs to modulate safe heart rate and blood pressure response. Material and Methods: We employed an intraneural electrode designed for the VN of pigs to perform VN stimulation (VNS). This was delivered using different numbers of contacts on the electrode and different stimulation parameters (amplitude, frequency, and pulse width), identifying the most suitable stimulation configuration. All the parameter ranges had been selected from a computational cardiovascular system model. Results: Clinically relevant responses were observed when stimulating with low current intensities and relatively low frequencies delivered with a single contact. Selecting a biphasic, charge-balanced square wave for VNS with a current amplitude of 500 μA, frequency of 10 Hz, and pulse width of 200 μs, we obtained heart rate reduction of 7.67 ± 5.19 beats per minute, systolic pressure reduction of 5.75 ± 2.59 mmHg, and diastolic pressure reduction of 3.39 ± 1.44 mmHg. Conclusion: Heart rate modulation was obtained without inducing any observable adverse effects, underlining the high selectivity of the intraneural approach.
Bioelectronic medicine , heart rate modulation , intraneural electrode , intraneural stimulation , vagus nerve stimulation
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BioRobotics Institute, Department of Excellence in Robotics & AI, Scuola Superiore SantAnna, Pisa, Italy
Institut für Mikrosystemtechnik, University of Frieberg, IMTEK, Freiburg, Germany
Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center “Health Science,” Scuola Superiore SantAnna, Pisa, Italy
Health Research Institute, Al-Farabi Kazakh National University, Almaty, Kazakhstan
BioMedLab, Scuola Superiore SantAnna, Pisa, Italy
Fondazione Toscana G. Monasterio, Pisa, Italy
Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectric Interfaces, Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland
Bertarelli Foundation Chair in Translational NeuroEngineering, Centre for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
BioRobotics Institute
Institut für Mikrosystemtechnik
Unit of Translational Critical Care Medicine
Health Research Institute
BioMedLab
Fondazione Toscana G. Monasterio
Bertarelli Foundation Chair in Neuroprosthetic Technology
Bertarelli Foundation Chair in Translational NeuroEngineering
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