Enhanced Tumor Targeting: Curcumin-Loaded Chitosan Nanoparticles for Precision Drug Delivery: A Review
Afonin G. Ismaeel G.L. Al-Hussainy A.F. Hameed S.M. Abd B. Hussein L.A. Hamza H.H. Jalal S.S. Sharipova S. Massakbayev A. Pushkarskaya N. Ibragimova Z. Kaldybayeva A.
2024University of Kashan
Journal of Nanostructures
2024#14Issue 1285 - 294 pp.
Curcumin, a naturally occurring polyphenol, has shown promising anti-cancer properties, but its clinical application is hindered by poor bioavailability. Chitosan nanoparticles (CHNPs) have emerged as a potential solution to enhance curcumin delivery due to their biocompatibility, biodegradability, and ability to facilitate targeted drug delivery. This review focuses on the development and application of curcumin-loaded chitosan nanoparticles (Cur-CHNPs) for precision cancer therapy. It highlights recent advances in synthesis methods, characterization, and mechanisms of tumor targeting. Additionally, the review discusses the in vitro and in vivo studies that demonstrate the efficacy of Cur-CHNPs, and explores future directions for improving cancer treatment.
Chitosan , Curcumin , Drug Delivery , Nanoparticles
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Department of Oncology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Pharmacology, College of Pharmacy, University of Al-Ameed, Karbala, Iraq
College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
Department of Optics, College of Health and Medical Technology, Sawa University, Almuthana, Iraq
Al-Manara College for Medical Sciences, Amarah, Iraq
Mazaya University College, Iraq
Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq
College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq
Department of Pharmaceutical and Toxicological Chemistry, Kazakh National Medical University, Almaty, Kazakhstan
Kazakh National Medical University, Almaty, Kazakhstan
School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Oncology
Department of Pharmacology
College of Pharmacy
Department of Optics
Al-Manara College for Medical Sciences
Mazaya University College
Department of Medical Laboratories Technology
College of Pharmacy
Department of Pharmaceutical and Toxicological Chemistry
Kazakh National Medical University
School of Pharmacy
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