Regulation of TGFβ/SMAD signaling by long non-coding RNAs in different cancers: Dark Knight in the Castle of molecular oncology
Adylova A. Mukhanbetzhanovna A.A. Attar R. Yulaevna I.M. Farooqi A.A.
March 2021KeAi Communications Co.
Non-coding RNA Research
2021#6Issue 123 - 28 pp.
One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of carcinogenesis. TGFβ/SMAD has been shown to dualistically regulate cancer progression. Therefore, TGFβ/SMAD signaling behaves as a “double-edged sword” in molecular oncology. Accordingly, regulation of TGFβ/SMAD is multi-layered because of oncogenic and tumor suppressor long non-coding RNAs (LncRNAs). In this review, we have summarized most recent breakthroughs in our understanding related to regulation of TGFβ/SMAD signaling by lncRNAs. We have comprehensively analyzed how different lncRNAs positively and negatively regulate TGFβ/SMAD signaling in different cancers. We have gathered missing pieces of an incomplete jig-saw puzzle of lncRNA-interactome ranging from “sponge effects” of lncRNAs to mechanistic modulation of TGFβ/SMAD signaling by lncRNAs.
Cancer , Carcinogenesis , Non-coding RNAs , Oncology , Signaling
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Biomedical Engineering & Molecular Medicine PhD candidate, Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518060, Guangdong, China
Department of Healthcare Management, KSPH Kazakhstan Medical University, Almaty, Kazakhstan
Department of Obstetrics and Gynecology, Yeditepe University, Turkey
E. A. Buketov Karaganda University, Kazakhstan
Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan
Biomedical Engineering & Molecular Medicine PhD candidate
Department of Healthcare Management
Department of Obstetrics and Gynecology
E. A. Buketov Karaganda University
Institute of Biomedical and Genetic Engineering (IBGE)
10 лет помогаем публиковать статьи Международный издатель
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