The effect of AGTR1, AGТ, LPL, ADRB2 gene polymorphisms on central obesity in adolescents of the Kazakh population
Adiyeva M. Aukenov N. Nurzhanova A. Slamkhanova N. Kerimkulova A.
2023Comenius University in Bratislava
Bratislava Medical Journal
2023#124Issue 153 - 58 pp.
BACKGROUND: Abdominal obesity, usually measured by waist circumference and waist-to-hip ratio, is more closely related to metabolic dysfunctions that are associated with cardiovascular diseases than general obesity, which is usually assessed by body mass index. The purpose of our study was to study the distribution of alleles and genotypes AGTR1, AGТ, LPL and ADRB2 among adolescents of the Kazakh population and to identify the relationship of these genes with predictors of obesity. METHODS: The study involved 184 adolescents aged 15–18 years of the Kazakh population. RESULTS: As a result of the study, it was revealed that the G allele of the rs328 polymorphism of the LPL gene reduces the risk of developing abdominal obesity compared to the C allele.The C/G genotype reduces the risk of developing abdominal obesity. We have identifi ed among the studied adolescents of the Kazakh population an increase in the ratio of waist volume (WV) to hip volume (HV) among boys, which may in the future lead to obesity and cardiovascular diseases in general. CONCLUSION: It was also found that the G allele of the rs328 polymorphism of the LPL gene reduces the risk of abdominal obesity. Therefore, in addition to determining BMI, we recommend determining the ratio WV to HP. It was found that an increase in the ratio of WV/HV by 1 cm increases the chance of developing hypoapolipoproteinemia A1 (Tab. 4, Fig. 1, Ref. 23). Text in PDF www.elis.sk
ADRB2 , AGTR1 , AGТ , body mass index , LPL , obesity , waist-to-hip ratio
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NCJSC “Semey Medical University”, Kazakhstan
Department of Science and Human Resources, Ministry of Health of the Republic of Kazakhstan, Nur-Sultan, Kazakhstan
MSE on the ROEM “Mother and Child Center”, Kazakhstan
NCJSC «Astana Medical University», Kazakhstan
NCJSC “Semey Medical University”
Department of Science and Human Resources
MSE on the ROEM “Mother and Child Center”
NCJSC «Astana Medical University»
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