The molecular mechanisms and therapeutic potential of EZH2 in breast cancer
Adibfar S. Elveny M. Kashikova H.S. Mikhailova M.V. Farhangnia P. Vakili-Samiani S. Tarokhian H. Jadidi-Niaragh F.
1 December 2021Elsevier Inc.
Life Sciences
2021#286
Due to its high occurrence and mortality rate, breast cancer has been studied from various aspects as one of the cancer fields hot topics in the last decade. Epigenetic alterations are spoused to be highly effective in breast cancer development. Enhancer of zeste homolog 2 (EZH2) is an enzymatic epi-protein that takes part in most vital cell functions by its different action modes. EZH2 is suggested to be dysregulated in specific breast cancer types, particularly in advanced stages. Mounting evidence revealed that EZH2 overexpression or dysfunction affects the pathophysiology of breast cancer. In this review, we discuss biological aspects of the EZH2 molecule with a focus on its newly identified action mechanisms. We also highlight how EZH2 plays an essential role in breast cancer initiation, progression, metastasis, and invasion, which emerged as a worthy target for treating breast cancer in different approaches.
Breast cancer , EZH2 , Targeted-therapy
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Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
DS & CI Research Group, Universitas Sumatera Utara, Medan, Indonesia
Kazakh-Russian Medical University, Kazakhstan
Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russian Federation
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Immunology Board for Transplantation and Advanced Cellular Therapeutics (ImmunoTACT), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Integrated Medicine and Aging Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology
Student Research Committee
DS & CI Research Group
Kazakh-Russian Medical University
Department of Prosthetic Dentistry
Department of Immunology
Network of Immunity in Infection
Immunology Board for Transplantation and Advanced Cellular Therapeutics (ImmunoTACT)
Immunology Research Center
Student Research Committee
Department of Immunology
Integrated Medicine and Aging Research Center
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