Biologically Active Terpenoids Ligularia Macrophylla (Ledeb.) DC. аnd Technology of New Drug Substance
Adekenov S.M. Ugay V.L. Kadirberlina G.M. Adekenov B.S. Krasnokutskaya E.A.
14 July 2024Institute of Combustion Problems, al-Farabi Kazakh State National University
Eurasian Chemico-Technological Journal
2024#26Issue 275 - 84 pp.
The article presents the results of a chemical study of Ligularia macrophylla (Ledeb.) DC. The essential oil was isolated by hydrodistillation using a Clevenger apparatus and microwave extraction using a NEOS installation. Using mass spectrometry, 52 components were identified in the essential oil isolated by hydrodistillation; 63 components were identified in the essential oil isolated by microwave extraction. The main components of the essential oil are Δ3-carene, β-bisabolene, β-myrcene. It was revealed that the substance obtained from the essential oil of Ligularia macrophylla (Ledeb.) DC. has anti-inflammatory and antimicrobial activity. For the first time, the optimal technological parameters for alcohol extraction of Ligularia macrophylla (Ledeb.) DC roots were determined using the method of mathematical modeling, providing a quantitative yield of the sesquiterpene lactone furanoeremophilan-14β,6α-olide, which has anti-inflammatory activity.
6α-olide , Biological activity , Essential oil , Extraction , Furanoeremophilan-14β , Hydrodistillation , Ligularia macrophylla (Ledeb.) DC , Mathematical modelling , Microwave extraction
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JSC “Research and Production Center “Phytochemistry”, Karaganda, 100009, Kazakhstan
NJSC “Karagandy University of the name of academician E.A. Buketov“, Karaganda, 100026, Kazakhstan
National Research Tomsk Polytechnic University, Tomsk, 634050, Russian Federation
JSC “Research and Production Center “Phytochemistry”
NJSC “Karagandy University of the name of academician E.A. Buketov“
National Research Tomsk Polytechnic University
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