The impact of vitamin D deficiency on female fertility and pregnancy performance: A literature review
Abshekenova A.T. Rybina A.N. Karibaeva S.K.
1 April 2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 126 - 33 pp.
Relevance: Preparation for pregnancy is an important stage that requires a comprehensive approach to a woman’s health. One key factor in successful preparation for pregnancy is the optimal level of micronutrients, including vitamins and minerals, which play a crucial role in regulating reproductive function. Particular attention should be paid to vitamin D, the deficiency of which is associated with a decrease in ovarian reserve, menstrual irregularities, and an increased risk of pregnancy complications. The study aimed to analyze modern data on the impact of vitamin D deficiency on fertility and pregnancy. Materials and Methods: The study used data from systematic reviews and original articles published between 2017 and 2024 from the international PubMed, MedLine, and Cochrane databases. The search yielded 45 sources, of which 30 clinical studies and registration data on the role of micronutrients in maintaining reproductive health and preventing pregnancy complications were included in the final analysis. Results: The data on the importance of vitamin D and other micronutrients in preparing for pregnancy and maintaining female fertility were analyzed. Vitamin D deficiency can reduce the likelihood of successful conception and increase the risk of pregnancy complications, including preeclampsia, gestational diabetes, and premature birth. Conclusion: The data obtained confirm the importance of optimal vitamin D levels and other micronutrients in preparing for pregnancy and maintaining fertility. The review results can form the basis for developing more accurate recommendations for correcting women’s nutritional status when planning pregnancy to increase the likelihood of conception and successful gestation.
infertility , micronutrients , polycystic ovarian syndrome (PCOS) , pre-conception preparation , pregnancy , vitamin D
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PERSONA International Clinical Center of Reproductology, Kazakh National Medical University named after S.D. Asfendiyarov, Almaty, Kazakhstan
Kazakh National Medical University, PERSONA International Clinical Center of Reproductology, Almaty, Kazakhstan
PERSONA International Clinical Center of Reproductology
Kazakh National Medical University
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