Mucoadhesive gellan gum/poly(2-ethyl-2-oxazoline) films for ocular delivery of pilocarpine hydrochloride
Abilova G.K. Nasibullin S.F. Ilyassov K. Adilov A.N. Akhmetova M.K. Moustafine R.I. Muratov Y.T. Kudaibergenov S.E. Khutoryanskiy V.V.
February 2025Editions de Sante
Journal of Drug Delivery Science and Technology
2025#104
The study aims to develop new prolonged delivery systems of pilocarpine hydrochloride (pilocarpine⸱HCl) for the therapy of glaucoma. Polymer films based on gellan gum (GG) and its mixtures with poly(2-ethyl-2-oxazoline) (POZ) at different ratios were prepared by casting. The films were found to be homogeneous, transparent, and sufficiently flexible. The GG:POZ mixtures were examined using spectroscopic, thermal and microscopic methods. Additionally, the mechanical and mucoadhesive properties of GG and GG:POZ films were studied. It was found that the greater content of gellan gum in the mixture enhances the mechanical strength and mucoadhesive properties of GG:POZ films. In vivo experiments in rabbits were conducted to evaluate the practical application of these films loaded with pilocarpine hydrochloride. The results demonstrate the effectiveness of the polymeric films compared to traditional eye drops in terms of prolonged release of the miotic drug and extended therapeutic effect duration.
Films , Gellan gum , Glaucoma , Miscibility , Mucoadhesion , Ocular drug delivery , Pilocarpine hydrochloride , poly(2-oxazoline)
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K. Zhubanov Aktobe Regional State University, Aktobe, 030000, Kazakhstan
Institute of Pharmacy, Kazan State Medical University, Kazan, 420126, Russian Federation
West Kazakhstan Medical University Named After M. Ospanov, Aktobe, 030000, Kazakhstan
Institute of Polymer Materials and Technologies, Almaty, 050019, Kazakhstan
School of Pharmacy, University of Reading, Reading, Whiteknights, RG6 6AD, United Kingdom
K. Zhubanov Aktobe Regional State University
Institute of Pharmacy
West Kazakhstan Medical University Named After M. Ospanov
Institute of Polymer Materials and Technologies
School of Pharmacy
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