Impact of Vitamin D Metabolism Disorders on the Development of Autoimmune Kidney Diseases: A systematic Review
Abilov T. Ismailova I. Shaimbetov Z. Imanbayev N. Iztleuov Y.
January 2025Georgian Association of Business Press
Georgian Medical News
2025#363Issue 623 - 38 pp.
Introduction: Vitamin D plays a crucial role in immune regulation and renal physiology. It acts as a modulator of both the innate and adaptive immune systems. Vitamin D enhances the differentiation of monocytes into macrophages, thereby strengthening their phagocytic and chemotactic functions. Its deficiency has been associated with the pathogenesis of autoimmune renal diseases; however, the clinical and molecular mechanisms underlying this association remain insufficiently understood. Aim: This systematic review focused on systemic lupus erythematosus with lupus nephritis (LN), IgA nephropathy (IgAN), and ANCA-associated vasculitis (AAV). The objective was to identify and synthesize available literature addressing the association between autoimmune kidney diseases and the dysregulation of vitamin D metabolism. Methods: Studies published between 2020 and 2025 were retrieved from the Cochrane Library, Google Scholar, Scopus, Web of Science, and PubMed. The inclusion criteria emphasized investigations assessing vitamin D status and metabolism within the context of autoimmune kidney diseases. Results: The analysis demonstrated that patients with LN, IgAN, and AAV exhibit a high prevalence of vitamin D deficiency, with rates frequently exceeding 70 percent. These values serve as descriptive summaries rather than as combined or pooled estimates.
ANCA vasculitis , IgA nephropathy , Immune dysregulation , lupus nephritis , nephroimmunology
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Candidate of Medical Science, Dean of the Faculty of General Medicine, Administrative and Management Personnel (AMP), NJSC «Marat Ospanov West Kazakhstan Medical University», Aktobe, Kazakhstan
Candidate of Medical Sciences, Associate Professor, Department of General Practitioner No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Pavlodar Region Branch of the Social Health Insurance Fund, Pavlodar, Kazakhstan
Department of Oncology, NJSC «Marat Ospanov West Kazakhstan Medical University», Aktobe, Kazakhstan
Candidate of Medical Sciences, Head of the Department of Radiology, NJSC «Marat Ospanov West Kazakhstan Medical University», Aktobe, Kazakhstan
Candidate of Medical Science
Candidate of Medical Sciences
Pavlodar Region Branch of the Social Health Insurance Fund
Department of Oncology
Candidate of Medical Sciences
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