Phytochemical Screening Using LC-MS to Study Antioxidant and Toxicity Potential of Methanolic Extracts of Atraphaxis pyrifolia Bunge
Abilkassymova A. Aldana-Mejía J.A. Katragunta K. Kozykeyeva R. Omarbekova A. Avula B. Turgumbayeva A. Datkhayev U.M. Khan I.A. Ross S.A.
September 2024Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2024#29Issue 18
Atraphaxis pyrifolia, a native medicinal plant of Central Asia, has a long history of traditional medicinal use; however, scientific research on its phytochemical and biological properties remains scarce. This paper aims to elucidate its chemical profile and assess its pharmacological potential through a comprehensive investigation of the phytochemical composition of stems and leaves using Liquid Chromatography-Mass Spectrometry (LC-MS), in conjunction with the assessment of its antioxidant (DPPH and ABTS) and cytotoxicity test on Artemia salina. Predominantly, glycosylated flavonoids were detected in stems and leaves extracts, notably including 8-Acetoxy-3′,4′,5,5′-tetrahydroxy-7-methoxy-3-α-L-rhamno-pyranosyloxyflavone, pyrifolin, and dehydroxypyrifolin. While the latter compound is exclusive to A. pyrifolia, the former compounds serve as shared chemical markers with other Atraphaxis species. The methanolic extracts of A. pyrifolia leaves exhibited significant antioxidant capacity without toxicity against Artemia salina. This study contributes to current research through providing valuable insights into the chemical diversity and potential medicinal properties of this plant species.
antioxidant , Atraphaxis species , cytotoxicity , glycosylated flavonoids , therapeutic applications
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Higher School of Medicine, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, 050012, Kazakhstan
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, 38677, MS, United States
Faculty of Pharmacy, South Kazakhstan Medical Academy, Shymkent, 160019, Kazakhstan
Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, 38677, MS, United States
Higher School of Medicine
School of Pharmacy
National Center for Natural Products Research
Faculty of Pharmacy
Department of Biomolecular Sciences
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