Global trends and collaborative networks in gut microbiota-insulin resistance research: a comprehensive bibliometric analysis (2000–2024)

Abildinova G.Z. Benberin V.V. Vochshenkova T.A. Afshar A. Mussin N.M. Kaliyev A.A. Zhussupova Z. Tamadon A.
2024 Frontiers Media SA

Frontiers in Medicine
2024 #11

Background: The human gut microbiota plays a crucial role in maintaining metabolic health, with substantial evidence linking its composition to insulin resistance. This study aims to analyze the global scholarly contributions on the relationship between intestinal microbiota and insulin resistance from 2000 to 2024. Methods: A bibliometric analysis was conducted using data from Scopus and Web of Science Core Collection. The search strategy included terms related to “Gastrointestinal Microbiome” and “Insulin Resistance” in the title or abstract. Results: The analysis of 1,884 relevant studies from 510 sources was conducted, revealing a mean citation of 51.36 per manuscript and a remarkable annual growth rate of 22.08%. The findings highlight the significant role of gut microbiota in insulin resistance, corroborating prior studies that emphasize its influence on metabolic disorders. The literature review of the current study showed key mechanisms include the regulation of short-chain fatty acids (SCFAs) and gut hormones, which are critical for glucose metabolism and inflammation regulation. The analysis also identifies “Food and Function” as the most productive journal and Nieuwdorp M. as a leading author, underscoring the collaborative nature of this research area. Conclusion: The consistent increase in publications in the field of gut microbiota and insulin resistance indicates growing recognition of the gut microbiota’s therapeutic potential in treating insulin resistance and related metabolic disorders. Future research should focus on standardizing methodologies and conducting large-scale clinical trials to fully realize these therapeutic possibilities. Copyright

gastrointestinal microbiome , gut microbiota , insulin resistance , insulin sensitivity , short-chain fatly acids

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Gerontology Center, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Corporate Foundation, Institute of Innovative and Preventive Medicine, Astana, Kazakhstan
Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
PerciaVista R&D Co., Shiraz, Iran
Department of Surgery No. 2, West Kazakhstan Medical University, Aktobe, Kazakhstan
Department of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Gerontology Center
Corporate Foundation
Student Research Committee
PerciaVista R&D Co.
Department of Surgery No. 2
Department of Neurology
Department of Natural Sciences
Stem Cells Technology Research Center

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