Factors Associated with Tuberculosis Relapses Development

Факторы, ассоциированные с развитием рецидива туберкулеза
Abilbayeva A.A. Tarabaeva A.S. Okhas I.M. Kuashova D.K. Khaertynova I.M. Shuralev E.A.
2022 New Terra Publishing House

Tuberculosis and Lung Diseases
2022 #100 Issue 10 30 - 36 pp.

The objective: to identity socio-dcmographic, clinical and laboratory factors associated with tuberculosis recurrence. Subjects and Methods. Clinical and laboratory data of 208 TB patients treated at the National Scientific Center for Phthisiopulmonology of the Ministry of I lealth of the Republic of Kazakhstan were analyzed. IL-2 to the AlaDI I was assessed using test platforms Lionex GmbI I (Germany) according to the manufacturers instructions. SPSS 23.0 software was used for statistical processing of obtained data. To assess the significance of differences in groups, the Pearson Chi-Square test was used. To determine the factors associated with of the tuberculosis relapse, a multiple binary logistic regression analysis was carried out. Results. Multivariate logistic regression analysis confirmed that male gender (OR = 2.086, 95% CI 1.001-4.350, p = 0.050), drug resistance (OR = 4.910, 95% CI 1.923-12.534, p = 0.001), fibrosis cavernous tuberculosis (OR = 6.362, 95% CI 2.178-18.585, p = 0.001) and low level of sensitized T cells that synthesize I L-2 in response to exposure to the AlaDI I antigen in IGRA in vitro (OR = 2.155,95% CI 1.060-4.379, p = 0.034) were significantly associated with tuberculosis recurrence.

AlaDH , fibrous-cavernous tuberculosis , IL-2 , risk factors , tuberculosis relapse

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Kazakh National Medical University Named after S. D. Asfendiyarov, Almaty, Kazakhstan
Kazan State Medical Academy, Branch of Russian Medical Academy of Continuing Professional Education, Kazan, Russian Federation
Kazan Federal University, Kazan, Russian Federation
Kazan State Academy of Veterinary Medicine Named after N. E. Bauman, Kazan, Russian Federation

Kazakh National Medical University Named after S. D. Asfendiyarov
Kazan State Medical Academy
Kazan Federal University
Kazan State Academy of Veterinary Medicine Named after N. E. Bauman

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