Factors associated with fibro-cavernous tuberculosis
Abilbayeva A. Tarabayeva A. Myrkassymova A. Abubakirov A. Khaertynova I. Shuralev E.
2022National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2022#19Issue 528 - 33 pp.
Objective: To identify socio-demographic, clinical and laboratory risk factors associated with fibro-cavernous tuberculosis. Material and methods: Clinical and laboratory data of 184 patients with pulmonary tuberculosis who were treated at the National Scientific Center for Phthisiopulmonology of the Ministry of Healthcare of the Republic of Kazakhstan were analyzed. Specific antibodies to the lipoglycan of M.tuberculosis (MBT) were evaluated in an immunochromatographic assay. To assess the significance of differences in groups, the Pearson Chi-Square test was used. To determine factors associated with the fibro-cavernous tuberculosis, а multiple binary logistic regression analysis was carried out. Results: Multivariate logistic regression analysis showed that low BMI (OR=5,719, 95% CI: 2,049–15,965, p=0,001), TB recurrence (OR=3.374, 95% CI: 1,191–9,561, p=0,022), and a negative specific production of antibodies to lipoglycan of M.tuberculosis (MBT) (OR=0,354, 95% CI: 0,126-0,995, p=0,049) were significantly associated with fibro-cavernous tuberculosis. Conclusion: Weight deficiency, high antibodies levels and TB relapse are factors associated with fibro-cavernous tuberculosis.
anti-tuberculosis antibodies , fibro-cavernous tuberculosis , infiltrative tuberculosis , risk factors
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Department of General Immunology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Biostatistics and Basics of Scientific Research, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Phthisiopulmonology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Infectious Diseases, Kazan State Medical Academy – a branch of the federal state budgetary educational institution of additional professional education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Health of the Russian Federation, Tatarstan, Kazan, Russian Federation
Department of Applied Ecology, Institute of Environmental Sciences, Kazan Federal University, Tatarstan, Kazan, Russian Federation
Department of General Immunology
Department of Biostatistics and Basics of Scientific Research
Department of Phthisiopulmonology
Department of Infectious Diseases
Department of Applied Ecology
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