Hepatic insulin synthesis increases in rat models of diabetes mellitus type 1 and 2 differently
Abidov M. Sokolova K. Danilova I. Baykenova M. Gette I. Mychlynina E. Ozgur B.A. Gurol A.O. Yilmaz M.T.
November 2023Public Library of Science
PLoS ONE
2023#18Issue 11 November
Insulin-positive (+) cells (IPCs), detected in multiple organs, are of great interest as a probable alternative to ameliorate pancreatic beta-cells dysfunction and insulin deficiency in diabetes. Liver is a potential source of IPCs due to it common embryological origin with pancreas. We previously demonstrated the presence of IPCs in the liver of healthy and diabetic rats, but detailed description and analysis of the factors, which potentially can induced ectopic hepatic expression of insulin in type 1 (T1D) and type 2 diabetes (T2D), were not performed. In present study we evaluate mass of hepatic IPCs in the rat models of T1D and T2D and discuss factors, which may stimulate it generation: glycaemia, organ injury, involving of hepatic stem/progenitor cell compartment, expression of transcription factors and inflammation. Quantity of IPCs in the liver was up by 1.7-fold in rats with T1D and 10-fold in T2D compared to non-diabetic (ND) rats. We concluded that ectopic hepatic expression of insulin gene is activated by combined action of a number of factors, with inflammation playing a decision role.
Text of the article Перейти на текст статьи
Institute of Immunopathology and Preventive Medicine, Ljubljana, Slovenia
Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russian Federation
Kostanay Oblast Tuberculosis Dispensary, Kostanay, Kazakhstan
Department of Medical Biology and Genetics, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey
Diabetes Application and Research Center, Demiroglu Bilim University, Istanbul, Turkey
Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
Diabetes Application and Research Center, Istanbul University, Istanbul, Turkey
International Diabetes Center, Acibadem University, Istanbul, Turkey
Institute of Immunopathology and Preventive Medicine
Institute of Immunology and Physiology
Kostanay Oblast Tuberculosis Dispensary
Department of Medical Biology and Genetics
Diabetes Application and Research Center
Department of Immunology
Diabetes Application and Research Center
International Diabetes Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026