CLINICAL AND GENETIC FEATURES OF PERSONALIZED ANTIPSYCHOTIC THERAPY OF PATIENTS WITH PARANOID SCHIZOPHRENIA OF THE KAZAKH ETHNIC GROUP IN THE REPUBLIC OF KAZAKHSTAN
Abetova A.A. Raspopova N.I. Yessimov N.B. Prilutskaya M.V. Cherchenko N.N. Kachiyeva Z.S.
September 2023Georgian Association of Business Press
Georgian Medical News
2023#342Issue 980 - 90 pp.
The problems of schizophrenia therapy occupy a leading place in both foreign and domestic clinical psychiatry. The paper presents the results of a study to identify reliable biomarkers for predicting antipsychotic therapy of patients with paranoid schizophrenia of the Kazakh ethnic group in the Republic of Kazakhstan, conducted within the framework of the project: National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan IRN OP12165486. The effectiveness and tolerability of antipsychotic drugs used in the treatment of paranoid schizophrenia in the Republic of Kazakhstan according to clinical treatment protocols are analyzed. Gender and age-specific dynamics in the clinic of paranoid schizophrenia in antipsychotic therapy in persons of Kazakh ethnicity are described. Certain genetic features of representatives of the Kazakh ethnic group have been identified, which can influence the effectiveness and tolerability of antipsychotic drugs, which determines the basis of an innovative approach to personalized therapy of paranoid schizophrenia in patients of the Kazakh ethnic group in the Republic of Kazakhstan.
antipsychotic therapy , biomarkers , genetics , Kazakh ethnic , Kazakhstan , Paranoid schizophrenia
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Republican Scientific and Practical Center of Mental Health, Almaty, Kazakhstan
Kazakh National Medical University named after S.D. Asfendiyarov, Kazakhstan
Kazakh-Russian Medical University, Almaty, Kazakhstan
Semey Medical University, Semey, Kazakhstan
Republican Scientific and Practical Center of Mental Health
Kazakh National Medical University named after S.D. Asfendiyarov
Kazakh-Russian Medical University
Semey Medical University
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