Cetyltrimethylammonium bromide (Ctab)-loaded sio2–ag mesoporous nanocomposite as an efficient antibacterial agent
Abduraimova A. Molkenova A. Duisembekova A. Mulikova T. Kanayeva D. Atabaev T.Sh.
February 2021MDPI AG
Nanomaterials
2021#11Issue 21 - 9 pp.
To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss of antibacterial activity over time. Furthermore, it is still chal-lenging to collect small-sized Ag nanomaterials right after the synthesis process. In this study, spherical-shaped Ag nanoparticles (NPs) (~6–10 nm) were attached on the surface of cetyltrime-thylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) (~100–110 nm). Antibacterial activity tests suggested that the obtained nanocomposite can be used as a highly efficient antibacterial agent against both Gram-negative and Gram-positive bacterial strains. The min-imum inhibitory concentration (MIC) recalculated to pure Ag weight in nanocomposite was found to be ~1.84 µg/mL (for Escherichia coli) and ~0.92 µg/mL (for Staphylococcus aureus)—significantly smaller compared to values reported to date. The improved antibacterial activity of the prepared nanocomposite can be attributed to the even distribution of non-aggregated Ag NPs per volume unit and the presence of CTAB in the nanocomposite pores.
Antibac-terial activity , Cetyltrimethylammonium bromide , Mesoporous silica , Nanocomposite , Silver
Text of the article Перейти на текст статьи
Department of Biology, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Chemistry, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Biology
Department of Chemistry
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026