Functional tests in children with type 1 diabetes and their correlation with hemoglobin A1c levels

Abdulina V.R. Stepanova I.S.
2022 Medicine-Inform LLC

Russian Journal of Clinical Ophthalmology
2022 #22 Issue 2 99 - 102 pp.

Aim: To assess correlations between ocular ultrasound (US) biometry and optical coherence tomography (OCT) and hemoglobin A1c (HbA1c) in children with type 1 diabetes (T1D). Patients and Methods: 79 children were enrolled. The control group included 52 age-matched healthy children. Axial length (AL, mm) and lens thickness (LT, mm) were measured by US. Central corneal thickness (CCT) and central macular thickness (CMT) were measured by OCT (Cirrus 2000, Carl Zeiss Meditec, Germany). Correlation analysis to assess the relationship between HbA1c, US, and OCT was performed. Results: 55.7% of the participants were boys (n=44) and 44.3% were girls (n=35). Children were assigned into six groups depending on HbA1c levels. Group 1 (HbA1c <6.0%) included 8 children, group 2 (HbA1c 6.1-7.0%) 29 children, group 3 (HbA1c 7.1-8.0%) 21 children, group 4 (HbA1c 8.1-9.0%) 8 children, group 5 (HbA1c 9.1-10%) 5 children, and group 6 (HbA1c >10%) 8 children. The mean AL was 22.7±1.1 mm. The greatest AL was reported in groups 2 and 4, while the least AL was reported in groups 3 and 6. The greatest LT was reported in groups 4 and 6. In group 1, LT was similar to those in the control group. In all groups but group 2, CCT was greater than in controls. CMT demonstrated a negative correlation with HbA1c levels in the study groups. CMT was the greatest in children with T1D of 5 years’ duration. Conclusion: In children with T1D, US and OCT findings correlate with HbA1c levels and T1D duration. Ocular biometry, CCT, and CMT measurements are useful tests illustrating the level of compensation of systemic disease. Dynamic assessment of these parameters will help develop indicators of diabetic retinopathy in children with T1D.

Diabetes , Glycated hemoglobin , Optical coherence tomography , Ultrasound

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Department of Ophthalmology, Kazakhstan Russian Medical University, 71 Torekulov str, Almaty, 050012, Kazakhstan

Department of Ophthalmology

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