Total serum IgA levels and HLA-DQB1*02:01 allelic status

Abdukhakimova D. Ibrayeva M. Dossybayeva K. Turganbekova A. Zhanzakova Z. Abdrakhmanova S. McLoone P. Poddighe D.
February 2024 Springer

Immunologic Research
2024 #72 Issue 1 167 - 173 pp.

Immunoglobulin A Deficiency (IgAD) is the most common primary immunodeficiency and is significantly associated with Celiac Disease (CD), which recognizes a specific background of human leukocyte antigens (HLA) predisposition (including HLA-DQB1*02:01 allele). A number of studies investigated the role of HLA in IgAD etiopathogenesis: HLA-DQB1*02 alleles are included in the main haplotypes linked to this primary immunodeficiency. In this preliminary study, we investigated the potential impact of HLA-DQB1*02:01 allelic status on total serum IgA levels: 108 serum samples from the bone marrow donors’ registry were analyzed for total IgA concentration with respect to the HLA-DQB1*02:01 status. Although total serum IgA levels between HLA-DQB1*02:01 carriers and HLA-DQB1*02:01 negative donors were not different, we observed a statistically significant difference (p=0.0118) in total serum IgA levels among donors with low IgA concentration (<80mg/dL) in the sub-analysis between HLA-DQB1*02:01 positive group (including both homozygous and heterozygous carriers) compared to HLA-DQB1*02:01 negative donors. Our results might suggest a role of HLA-DQB1*02:01 allelic variant in the determination of total serum IgA levels, at least in patients affected with IgA deficiency and/or otherwise predisposed to it; however, larger and more standardized studies are needed to confirm this speculation.

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School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
Research and Production Center of Transfusion Medicine, Ministry of Health of the Republic of Kazakhstan, Astana, Kazakhstan
Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, University Medical Center, Astana, 010000, Kazakhstan

School of Medicine
Research and Production Center of Transfusion Medicine
Clinical Academic Department of Pediatrics

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