APPLICATION OF THROMBOLYSIS THERAPY FOR ACUTE CEREBRAL CIRCULATION IN THE REPUBLIC OF KAZAKHSTAN, COUNTRIES OF THE FAR AND NEAR FOREIGN COUNTRIES

Abdrakhmanova M.G. Kasenova A.S. Omarova Sh. Shinalieva K.A. Baltabaeva A.S.
May 2022 Georgian Association of Business Press

Georgian Medical News
2022 #326 Issue 5 36 - 39 pp.

In the world, stroke suffers 5.6-6 million people a year. Stroke deaths are predicted to rise to 6.7 million in 2015 and to 7.8 million in 2030. Stroke is the leading cause of disability worldwide. The provision of specific therapy to patients with stroke in the form of thrombolytic therapy and neurosurgical operations are recognized international standards in the provision of medical care. The advent of computed tomography (CT) in the early 1980s made it possible to further study TLT. In 2014 Joanna M WardlawVeronic, MurrayEivind, Berge Gregory, J del Zoppo searched the Cochrane Stroke Trial Registry (Last November 2013), MEDLINE (1966 to November 2013) and at EMBASE (from 1980 to November 2013). We concluded that thrombolytic therapy administered within six hours of a stroke reduces the proportion of deaths or disability. The dependence of the efficacy and safety of fibrinolytic therapy on the time of its initiation has been demonstrated in a number of large studies. A pooled analysis of the results of the NINDS, ECASS I and II, ATLANTIS studies (n = 2775) showed that the odds ratio (OR) of a favorable outcome of the disease when thrombolysis was initiated in the first 90 minutes of a stroke. Thus, time is the most important condition for the effectiveness of TLT. In addition to the time factor, it is important to take into account the age of patients during TLT. F. Mateen et al. analyzed data from the Canadian TLT registry for patients aged 80 to 89 years and 90 to 99 years. Thus, thrombolysis in patients of various age groups, including those aged 80 to 89 years and older, is equally safe and effective.

ATLANTIS (A and B) , ECASS I , II , III , Ischemic stroke , NINDS studies , stroke in the CIS countries , thrombolytic therapy

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NJSC Astana Medical University, Ministry of Health of the Republic of Kazakhstan, Nur-Sultan, Kazakhstan

NJSC Astana Medical University

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