Cryoballoon ablation for the treatment of atrial fibrillation in Kazakhstan: One year outcome from the Cryo Global Registry
Abdrakhmanov A. Nuralinov O. Rashbayeva G. Tursunbekov A. Bagibayev S. Bakytzhanuly A. Yessilbayev Z. Chinybayeva A. Abdrakhmanova Z. Salustri A. Suleymen Z. Kirkimbayeva R.
1 September 2025Indian Pacing and Electrophysiology Group
Indian Pacing and Electrophysiology Journal
2025#25Issue 5294 - 301 pp.
Introduction: Atrial fibrillation (AF) is a prevalent and potentially serious cardiac rhythm disorder. Cryoballoon ablation using the Arctic Front catheter offers a modern treatment approach. This subanalysis evaluates the safety, efficacy, and impact on quality of life for patients undergoing t this procedure in Kazakhstan. The Cryo AF Global Registry (NCT02752737) is an ongoing prospective, multi-center observational post-market registry collecting global data on CBA procedures conducted with the Arctic Front™ Family of Cardiac Cryoablation Catheters. Methods: The study included patients aged 18 and older with paroxysmal, persistent, and long-standing persistent AF. Key safety endpoints included serious adverse events related to the device or procedure. Efficacy was measured by the absence of AF, atrial flutter (AFL), and/or atrial tachycardia (AT) after a 90-day period of discontinuing antiarrhythmic medications. Results: No injuries to the phrenic nerve or serious complications were reported. Three serious adverse events occurred, but these were not related to the procedure. At 12 months, the Kaplan-Meier analysis showed a 92.9 % rate of freedom from AF or other atrial arrhythmias after the 90-day blanking period. Two repeat ablations (2.9 %) were needed for AF. Conclusion: This analysis supports the conclusion that cryoballoon ablation is both safe and effective for treating AF in Kazakhstan, resulting in significant improvements in patients quality of life. Registration number: NCT02752737.
Arctic Front , Cryo registry , Cryoballoon ablation , Kazakhstan
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Department of Arrhythmology, National Research Cardiac Surgery Center, Astana, Kazakhstan
Department of Cardiology, Astana Medical University, Astana, Kazakhstan
Department of Arrhythmology, Medical Centre Hospital of the Presidents Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Arrhythmology
Department of Cardiology
Department of Arrhythmology
Department of Medicine
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