The Impact of High-Fat Diet and Circadian Disruptions on Obesity and Immune System Dysfunction
Abdolla N. Narmuratova G. Abdusattarova Y. Kali A. Perfilyeva Y. Ostapchuk Y. Tleulieva R. Ydyrys A.
June 2025Engineered Science Publisher
ES Food and Agroforestry
2025#20
Obesity, as a chronic health condition, is becoming the next major epidemiological problem facing modern society. It remains the leading cause of the development of several serious diseases, such as diabetes mellitus, cardiovascular diseases, cancer, and others, as well as death from these conditions. This has a significant impact on both the health sector and the economic sphere. High-fat diets (HFDs) are associated with an increased risk of obesity, which is linked to increased body weight in humans. Additionally, there is growing awareness of the role of the circadian rhythm system in the formation and progression of obesity. These factors have also been shown to cause disruptions in both innate and acquired immunity, with central and peripheral metainflammation characterizing obesity. In recent years, there has been an increase in scientific studies aimed at establishing new connections and uncovering the pathophysiological mechanisms underlying excessive weight gain and obesity. The goal of this review is to examine recent scientific literature and highlight the significance of the obesity problem, including its connections to high-fat diets and circadian rhythm disorders, as well as the impact of these factors on the immune system. Gaining further insight into the causal relationship between obesity, the circadian rhythm system, and the development of a chronic inflammatory response is both promising and essential for creating scientifically informed strategies for early intervention and timely correction of such disorders.
Circadian rhythm disruption , High-fat diet , Immunity , Inflammation , Obesity , Overweight
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M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St, Almaty, 050012, Kazakhstan
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi Avenue, 71, Almaty, 050038, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Avenue, 71, Almaty, 050038, Kazakhstan
M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry
Faculty of Biology and Biotechnology
Biomedical Research Centre
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