Protein/creatinine ratio versus 24-hours urine protein in preeclampsia

Abdelazim I.A. Amer O.O. Shikanova S. Karimova B.
2022 Via Medica

Ginekologia Polska
2022 #93 Issue 12 975 - 979 pp.

Objectives: Proteinuria is one of the diagnostic criteria of preeclampsia (PE). Measurement of 24-hour urine protein is the gold standard method for detection of proteinuria in PE. The 24-hour urine sampling is time-consuming, and inconvenient. To evaluate the accuracy of protein/creatinine (P/C) ratio in detection of significant proteinuria (> 1 g/24-hours urine) in PE. Material and methods: One hundred and ten (110) preeclamptic women were included in this study and admitted for blood pressure monitoring, 24-hour urine collection, fetal well-being assessment and spot urine sample for measuring of P/C ratio. After thorough history and clinical examination, routine antenatal investigations were done for the women included in the study according to the hospitals protocol, and to exclude pre-existing chronic renal disease. Twenty-four-hour urine collection started on the morning following hospital admission. Spot urine samples were obtained shortly before the 24-hour urine collection for measuring of P/C ratio. Collected data statistically analyzed to evaluate the accuracy of P/C ratio in detection of significant proteinuria in PE. Results: The P/C ratio of 1.35 ± 2.54 had 94.4% sensitivity, 94.9% specificity, 97.1% positive predictive value (PPV), 90.2% negative predictive value (NPV), and 94.5% overall accuracy in detection of significant proteinuria (> 1 g/24-hour urine) in PE. Conclusions: The P/C ratio of 1.35 ± 2.54 had 94.4% sensitivity, 94.9% specificity, 97.1% PPV, 90.2% NPV, and 94.5% overall accuracy in detection of significant proteinuria (> 1 g/24-hour urine) in PE. This study suggests the use of P/C ratio as an alternative to 24-hour urine protein to detect significant proteinuria in PE.

24-hour urine , Preeclampsia (pe) , Protein , Protein/creatinine ratio

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Department of Obstetrics and Gynaecology, Ain Shams University, Cairo, Egypt
Ahmadi Hospital, Kuwait Oil Company (KOC), Ahmadi, Kuwait
Ghamra Military Hospital, Cairo, Egypt
West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Department of Obstetrics and Gynaecology
Ahmadi Hospital
Ghamra Military Hospital
West Kazakhstan Marat Ospanov Medical University

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