Natural foci of plague in Kazakhstan in the space-time continuum
Abdel Z. Abdeliyev B. Yessimseit D. Begimbayeva E. Mussagalieva R.
September 2023Elsevier Ltd
Comparative Immunology, Microbiology and Infectious Diseases
2023#100
The relevance of the problem of the stated topic lies in the fact that the causative agent of the plague infection demonstrates high survival while maintaining high virulence in the territories, which are enzootic in terms of the plague. The study aimed to investigate the geographic distribution and genetic diversity of the plague pathogen in endemic regions through molecular genetic research. The work included the results of laboratory studies of 3058 samples, including soil – 1154, burrow substrates – 549, the contents of the feeding chamber – 349, bone remains – 18, biological objects – 988 samples of sera and suspensions from carriers and vectors of plague infection collected from 14 autonomous plague foci of Kazakhstan for the period 2021–2022. The leading method in the study was a laboratory experiment, thanks to which, using a new advanced technology on a microbiological analyser VITEK 2 COMPACT 30, it was possible to study pathogenic and non-pathogenic strains of the genus Yersinia isolated during field experiment. As a result of experimental work, it was shown that during a long inter-epizootic period, the plague pathogen can persist in the soil in symbiosis with soil microorganisms, and in this area, it chooses soil with a low-quality index of 10 points, where soils with a low total microbial number and species landscape prevail.
Acanthamoeba , Enzootic plague nuclei , Infection , Soil quality , Yersinia pestis
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Laboratory of Plague, Masgut Aikimbayev National Scientific Center for Especially Dangerous Infections of the Ministry of Healthcare of the Republic of Kazakhstan, Almaty, Kazakhstan
Department of Express Diagnostics and Indication of Especially Dangerous Infections, Masgut Aikimbayev National Scientific Center for Especially Dangerous Infections of the Ministry of Healthcare of the Republic of Kazakhstan, Almaty, Kazakhstan
Department of the National and Working Collection of Microorganisms, Masgut Aikimbayev National Scientific Center for Especially Dangerous Infections of the Ministry of Healthcare of the Republic of Kazakhstan, Almaty, Kazakhstan
Department of Organizational, Advisory and Methodological Work, Masgut Aikimbayev National Scientific Center for Especially Dangerous Infections of the Ministry of Healthcare of the Republic of Kazakhstan, Almaty, Kazakhstan
Laboratory of Plague
Department of Express Diagnostics and Indication of Especially Dangerous Infections
Department of the National and Working Collection of Microorganisms
Department of Organizational
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