Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis
Abay Z. Nurpeisova A. Shorayeva K. Sadikaliyeva S. Yespembetov B. Syrym N. Sarmykova M. Jekebekov K. Abitayev R. Tokkarina G. Kalimolda E. Absatova Z. Moldagulova S. Yoo H.S. Kassenov M. Zakarya K. Abduraimov Y.
July 2023Multidisciplinary Digital Publishing Institute (MDPI)
Vaccines
2023#11Issue 7
This study presents the results of a survey of the safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with the NS1 mutation and expressing M. bovis protective antigens ESAT-6 and TB10.4. We vaccinated Balb/c outbred mice two times at 21 days apart. Our experimental design includes mice immunised with the candidate vaccine with or without adjuvant 15% Montanide Gel. The candidate vaccine’s safety was determined by biometric analysis, and protective efficacy was assessed by bacteriological and histological experiments following a virulent M. bovis-8 strain challenge. Our data indicated that the adjuvant-free version of the vaccine ensured complete protection from the M. bovis-8 infection in mice.
bovine tuberculosis , histology , influenza vector , protective efficacy , safety
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Research Institute for Biological Safety Problems, Guardeyskiy uts, 080409, Kazakhstan
Department of Biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea
Research Institute for Biological Safety Problems
Department of Biotechnology
College of Veterinary Medicine
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