Experimental study comparing structural changes induced by biologic versus synthetic mesh implants in nephropexy
Abatova A.N. Tussupbekova M.M. Abatov N.T. Badyrov R.M. Kamyshanskiy Y.K.
2021Scientific Foundation SPIROSKI
Open Access Macedonian Journal of Medical Sciences
2021#9Issue A284 - 290 pp.
BACKGROUND: Long-term chronic inflammatory response when using meshes for nephropexy may lead to kidney fibrosis, renal failure, and chronic pain syndrome. Research on biological properties of various materials used for nephropexy, as well as the search for new implant materials is a pressing problem, as it greatly affects patients’ quality of life. The present study suggests that the use of the extracellular bovine-derived peritoneum matrix as a new biological implant opens up new prospects for nephropexy. AIM: This study aims to evaluate the structural changes at the interface of the renal tissues and paranephron with the extracellular bovine-derived peritoneum matrix and the UltraPro mesh after nephropexy in an experimental animal. MATERIALS AND METHODS: Experimental nephropexy was performed in 64 white shorthaired adult rats, divided into two groups: Extracellular bovine-derived peritoneum matrix and UltraPro mesh. Implants were 1.5 × 1.5 cm per one animal. Observation periods were 7, 21, 30, and 180 days. The tissue was stained with hematoxylin and eosin, Van Gieson’s with Pikro-Fuchsin. Cellular infiltrate was evaluated by counting granulocytes, mononuclear cells, and foreign body giant cells on five high-magnification images for each stained section (×400). RESULTS: The use of the extracellular bovine-derived peritoneum matrix induced less intense and less prolonged chronic inflammatory response, as well as intense production of new collagen fibers more similar to the native connective tissue in terms of their histologic structure. The UltraPro mesh induced moderately persistent chronic inflammatory response throughout the 6-month study period. By this period, the level of multinucleated foreign body giant cells in the UltraPro group was 1.0 ± 0.2, it was statistically significantly higher than in the group with extracellular bovine-derived peritoneum matrix – 0.6 ± 0.1 (p < 0.05). CONCLUSION: Histologic evaluation demonstrates high biocompatibility of both the extracellular bovine-derived peritoneum matrix and the UltraPro mesh implants. The results of using new biological material are not worse than synthetic mesh.
Bovine-derived peritoneum implant , Extracellular matrix , Morphometry , Nephropexy , UltraPro mesh
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Department of Surgical Diseases, Faculty of Medicine, Karaganda Medical University, Karagandy, Kazakhstan
Department of Pathology, Faculty of Medicine, Karaganda Medical University, Karagandy, Kazakhstan
Chief of Morphological Laboratory, Clinic of Karaganda Medical University, Karagandy, Kazakhstan
Department of Surgical Diseases
Department of Pathology
Chief of Morphological Laboratory
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